CydD

• Description: ABC transporter required for expression of cytochrome bd (ATP-binding protein)
  
  

Gene name	cydD
Synonyms	yxkN
Essential	no
Product	ABC transporter (ATP-binding protein)
Function	required for expression of cytochrome bd
Gene expression levels in SubtiExpress: cydD
Interactions involving this protein in SubtInteract: CydD
MW, pI	64 kDa, 6.221
Gene length, protein length	1725 bp, 575 aa
Immediate neighbours	yxkO, cydC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, respiration, membrane proteins

This gene is a member of the following regulons

CcpA regulon, ResD regulon, Rex regulon

The gene

Basic information

• Locus tag: BSU38730

Database entries

• BsubCyc: BSU38730

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: has both a membrane-spanning and an ATP-binding domain PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • CydD-CydC PubMed

• Localization: cell membrane PubMed

Database entries

• BsubCyc: BSU38730

• Structure:

• UniProt: P94367

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • cydA-cydB-cydC-cydD PubMed
  • cydD PubMed

• Expression browser: cydD PubMed

• Sigma factor:
  • cydA:
  • cydD: SigF PubMed

• Regulation:
  • repressed by glucose (CcpA)
  • induced under anaerobic conditions (Rex) PubMed
  • expressed under anaerobic conditions (ResD) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression
  • Rex: transcription repression PubMed
  • ResD: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ankita Puri-Taneja, Matthew Schau, Yinghua Chen, F Marion Hulett
Regulators of the Bacillus subtilis cydABCD operon: identification of a negative regulator, CcpA, and a positive regulator, ResD.
J Bacteriol: 2007, 189(9);3348-58
[PubMed:17322317] [WorldCat.org] [DOI] (P p)

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

Jonas T Larsson, Annika Rogstam, Claes von Wachenfeldt
Coordinated patterns of cytochrome bd and lactate dehydrogenase expression in Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 10);3323-3335
[PubMed:16207915] [WorldCat.org] [DOI] (P p)

Matthew Schau, Yinghua Chen, F Marion Hulett
Bacillus subtilis YdiH is a direct negative regulator of the cydABCD operon.
J Bacteriol: 2004, 186(14);4585-95
[PubMed:15231791] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

L Winstedt, K Yoshida, Y Fujita, C von Wachenfeldt
Cytochrome bd biosynthesis in Bacillus subtilis: characterization of the cydABCD operon.
J Bacteriol: 1998, 180(24);6571-80
[PubMed:9852001] [WorldCat.org] [DOI] (P p)