CueR

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  • Description: transcriptional regulator of the copZ-copA operon

Gene name cueR
Synonyms yhdQ
Essential no
Product transcriptional regulator (MerR family)
Function regulation of the copZ-copA operon
Metabolic function and regulation of this protein in SubtiPathways:
metal ion homeostasis
MW, pI 16 kDa, 7.886
Gene length, protein length 429 bp, 143 aa
Immediate neighbours yhdP, yhdR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YhdQ context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, resistance against toxic metals

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09560

Expression

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Nesha May Andoy, Susanta K Sarkar, Qi Wang, Debashis Panda, Jaime J Benítez, Aleksandr Kalininskiy, Peng Chen
Single-molecule study of metalloregulator CueR-DNA interactions using engineered Holliday junctions.
Biophys J: 2009, 97(3);844-52
[PubMed:19651042] [WorldCat.org] [DOI] (I p)

Gregory T Smaldone, John D Helmann
CsoR regulates the copper efflux operon copZA in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 12);4123-4128
[PubMed:18048925] [WorldCat.org] [DOI] (P p)

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)

Ahmed Gaballa, Min Cao, John D Helmann
Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon.
Microbiology (Reading): 2003, 149(Pt 12);3413-3421
[PubMed:14663075] [WorldCat.org] [DOI] (P p)