CueR

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  • Description: transcriptional regulator of the copZ-copA operon

Gene name cueR
Synonyms yhdQ
Essential no
Product transcriptional regulator (MerR family)
Function regulation of the copZ-copA operon
Gene expression levels in SubtiExpress: cueR
Metabolic function and regulation of this protein in SubtiPathways:
metal ion homeostasis
MW, pI 16 kDa, 7.886
Gene length, protein length 429 bp, 143 aa
Immediate neighbours yhdP, yhdR
Sequences Protein DNA Advanced_DNA
Genetic context
YhdQ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CueR expression.png
























Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, resistance against toxic metals

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09560

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Nesha May Andoy, Susanta K Sarkar, Qi Wang, Debashis Panda, Jaime J Benítez, Aleksandr Kalininskiy, Peng Chen
Single-molecule study of metalloregulator CueR-DNA interactions using engineered Holliday junctions.
Biophys J: 2009, 97(3);844-52
[PubMed:19651042] [WorldCat.org] [DOI] (I p)

Gregory T Smaldone, John D Helmann
CsoR regulates the copper efflux operon copZA in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 12);4123-4128
[PubMed:18048925] [WorldCat.org] [DOI] (P p)

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)

Ahmed Gaballa, Min Cao, John D Helmann
Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon.
Microbiology (Reading): 2003, 149(Pt 12);3413-3421
[PubMed:14663075] [WorldCat.org] [DOI] (P p)