Difference between revisions of "CtsR"

From SubtiWiki
Jump to: navigation, search
Line 13: Line 13:
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of protein degradation
 
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of protein degradation
 +
|-
 +
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 9.261   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 9.261   

Revision as of 10:47, 11 June 2009

  • Description: transcription repressor of class III heat shock genes (clpC operon, clpE, clpP)

Gene name ctsR
Synonyms yacG
Essential no
Product transcription repressor
Function regulation of protein degradation
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 17 kDa, 9.261
Gene length, protein length 462 bp, 154 aa
Immediate neighbours rrnW-5S, mcsA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CtsR context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU00830

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ctsR family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation of a tyrosine residue by McsB PubMed
  • Cofactor(s):
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism: CtsR: transcription repression PubMed
  • Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)

E Krüger, M Hecker
The first gene of the Bacillus subtilis clpC operon, ctsR, encodes a negative regulator of its own operon and other class III heat shock genes.
J Bacteriol: 1998, 180(24);6681-8
[PubMed:9852015] [WorldCat.org] [DOI] (P p)

  1. Petersohn et al. (2001) Global Analysis of the General Stress Response of Bacillus subtilis. J Bacteriol. 183: 5617-5631 PubMed
  2. Krüger E, Hecker M. (1998) The first gene of the Bacillus subtilis clpC operon, ctsR, encodes a negative regulator of its own operon and other class III heat shock genes. J Bacteriol. 180(24): 6681-8.. PubMed