Difference between revisions of "CtpB"

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|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[SigK]] activation
 
|style="background:#ABCDEF;" align="center"|'''Function''' || control of [[SigK]] activation
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU35240 ctpB]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35240 ctpB]
 
|-
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 52 kDa, 8.641   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 52 kDa, 8.641   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[swrAA/2]]'', ''[[ftsX]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[swrAA/2]]'', ''[[ftsX]]''
 
|-
 
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15541&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35240 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35240 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35240 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:yvjB_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yvjB_context.gif]]

Revision as of 13:58, 13 May 2013

  • Description: carboxy-terminal processing serine protease, cleaves SpoIVFA, this results in processing of pro-SigK

Gene name ctpB
Synonyms yvjB
Essential no
Product carboxy-terminal processing serine protease,
cleaves SpoIVFA
Function control of SigK activation
Gene expression levels in SubtiExpress: ctpB
MW, pI 52 kDa, 8.641
Gene length, protein length 1440 bp, 480 aa
Immediate neighbours swrAA/2, ftsX
Sequences Protein DNA Advanced_DNA
Genetic context
YvjB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CtpB expression.png

























Categories containing this gene/protein

proteolysis, sigma factors and their control, sporulation proteins

This gene is a member of the following regulons

SigE regulon, SigG regulon

The gene

Basic information

  • Locus tag: BSU35240

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): CtpA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: ctpB (according to DBTBS)
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Nathalie Campo, David Z Rudner
SpoIVB and CtpB are both forespore signals in the activation of the sporulation transcription factor sigmaK in Bacillus subtilis.
J Bacteriol: 2007, 189(16);6021-7
[PubMed:17557826] [WorldCat.org] [DOI] (P p)

Nathalie Campo, David Z Rudner
A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis.
Mol Cell: 2006, 23(1);25-35
[PubMed:16818230] [WorldCat.org] [DOI] (P p)

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)

Qi Pan, Richard Losick, David Z Rudner
A second PDZ-containing serine protease contributes to activation of the sporulation transcription factor sigmaK in Bacillus subtilis.
J Bacteriol: 2003, 185(20);6051-6
[PubMed:14526016] [WorldCat.org] [DOI] (P p)