Ctc

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Gene name ctc
Synonyms
Essential no
Product ribosomal protein
Function unknown
Gene expression levels in SubtiExpress: ctc
Interactions involving this protein in SubtInteract: Ctc
Metabolic function and regulation of this protein in SubtiPathways:
Nucleotides (regulation), Murein recycling
MW, pI 21 kDa, 4.216
Gene length, protein length 612 bp, 204 aa
Immediate neighbours prs, spoVC
Sequences Protein DNA DNA_with_flanks
Genetic context
Ctc context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Ctc expression.png



















Categories containing this gene/protein

translation, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

  • Locus tag: BSU00520

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: Ctc subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1FEU (from Thermus thermophilus, 32% identity, 53% similarity) PubMed
  • KEGG entry: [3]
  • E.C. number:

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

  • Mutant: GP500(spc), available in Stülke lab
  • Expression vector:
    • expression/ purification with N-terminal His-tag in E. coli: pGP804 (in pWH844), available in Stülke lab
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody: available in Stülke lab

Labs working on this gene/protein

Your additional remarks

References

Reviews

Additional reviews: PubMed


Original publications

Additional publications: PubMed

Dirk Höper, Uwe Völker, Michael Hecker
Comprehensive characterization of the contribution of individual SigB-dependent general stress genes to stress resistance of Bacillus subtilis.
J Bacteriol: 2005, 187(8);2810-26
[PubMed:15805528] [WorldCat.org] [DOI] (P p)

Matthias Schmalisch, Ines Langbein, Jörg Stülke
The general stress protein Ctc of Bacillus subtilis is a ribosomal protein.
J Mol Microbiol Biotechnol: 2002, 4(5);495-501
[PubMed:12432960] [WorldCat.org] (P p)

R Fedorov, V Meshcheryakov, G Gongadze, N Fomenkova, N Nevskaya, M Selmer, M Laurberg, O Kristensen, S Al-Karadaghi, A Liljas, M Garber, S Nikonov
Structure of ribosomal protein TL5 complexed with RNA provides new insights into the CTC family of stress proteins.
Acta Crystallogr D Biol Crystallogr: 2001, 57(Pt 7);968-76
[PubMed:11418764] [WorldCat.org] [DOI] (P p)

I Hilden, B N Krath, B Hove-Jensen
Tricistronic operon expression of the genes gcaD (tms), which encodes N-acetylglucosamine 1-phosphate uridyltransferase, prs, which encodes phosphoribosyl diphosphate synthetase, and ctc in vegetative cells of Bacillus subtilis.
J Bacteriol: 1995, 177(24);7280-4
[PubMed:8522540] [WorldCat.org] [DOI] (P p)

C L Truitt, E A Weaver, W G Haldenwang
Effects on growth and sporulation of inactivation of a Bacillus subtilis gene (ctc) transcribed in vitro by minor vegetative cell RNA polymerases (E-sigma 37, E-sigma 32).
Mol Gen Genet: 1988, 212(1);166-71
[PubMed:2836704] [WorldCat.org] [DOI] (P p)

C Ray, M Igo, W Shafer, R Losick, C P Moran
Suppression of ctc promoter mutations in Bacillus subtilis.
J Bacteriol: 1988, 170(2);900-7
[PubMed:3123466] [WorldCat.org] [DOI] (P p)

M M Igo, R Losick
Regulation of a promoter that is utilized by minor forms of RNA polymerase holoenzyme in Bacillus subtilis.
J Mol Biol: 1986, 191(4);615-24
[PubMed:3100810] [WorldCat.org] [DOI] (P p)

J F Ollington, W G Haldenwang, T V Huynh, R Losick
Developmentally regulated transcription in a cloned segment of the Bacillus subtilis chromosome.
J Bacteriol: 1981, 147(2);432-42
[PubMed:6790515] [WorldCat.org] [DOI] (P p)

W G Haldenwang, R Losick
A modified RNA polymerase transcribes a cloned gene under sporulation control in Bacillus subtilis.
Nature: 1979, 282(5736);256-60
[PubMed:116131] [WorldCat.org] [DOI] (P p)