Ctc

• Description: general stress protein, similar to ribosomal protein L25
  
  

Gene name	ctc
Synonyms
Essential	no
Product	ribosomal protein
Function	unknown
Gene expression levels in SubtiExpress: ctc
Interactions involving this protein in SubtInteract: Ctc
Metabolic function and regulation of this protein in SubtiPathways: ctc
MW, pI	21 kDa, 4.216
Gene length, protein length	612 bp, 204 aa
Immediate neighbours	prs, spoVC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

translation, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU00520

Database entries

• BsubCyc: BSU00520

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: Ctc subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • 5S rRNA-Ctc PubMed

• Localization: in the ribosome (large subunit) PubMed

Database entries

• BsubCyc: BSU00520

• Structure: 1FEU (from Thermus thermophilus, 32% identity, 53% similarity) PubMed

• UniProt: P14194

• KEGG entry: [3]

• E.C. number:

Additional information

• subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

• Operon:
  • gcaD-prs-ctc PubMed
  • ctc PubMed

• Expression browser: ctc PubMed

• Sigma factor:
  • gcaD: SigA PubMed
  • ctc: SigB PubMed

• Regulation: induced by stress (SigB) PubMed

• Regulatory mechanism: alternative sigma factor, SigB PubMed

• Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

• Mutant: GP500(spc), available in Stülke lab

• Expression vector:
  • expression/ purification with N-terminal His-tag in E. coli: pGP804 (in pWH844), available in Stülke lab

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: available in Stülke lab

References

Reviews

Additional reviews: PubMed