CtaB

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  • Description: heme O synthase (major enzyme)

Gene name ctaB
Synonyms
Essential no
Product heme O synthase (major enzyme)
Function heme biosynthesis
Gene expression levels in SubtiExpress: ctaB
MW, pI 33 kDa, 9.566
Gene length, protein length 915 bp, 305 aa
Immediate neighbours ctaA, ctaC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CtaB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CtaB expression.png
























Categories containing this gene/protein

biosynthesis of cofactors, membrane proteins

This gene is a member of the following regulons

ResD regulon

The gene

Basic information

  • Locus tag: BSU14880

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ubiA prenyltransferase family, Protoheme IX farnesyltransferase subfamily (according to Swiss-Prot)
  • Paralogous protein(s): CtaO

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • expressed under anaerobic conditions (ResD) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Tatsushi Mogi
Over-expression and characterization of Bacillus subtilis heme O synthase.
J Biochem: 2009, 145(5);669-75
[PubMed:19204012] [WorldCat.org] [DOI] (I p)

Brienne M Brown, Zhihong Wang, Kenneth R Brown, Julia A Cricco, Eric L Hegg
Heme O synthase and heme A synthase from Bacillus subtilis and Rhodobacter sphaeroides interact in Escherichia coli.
Biochemistry: 2004, 43(42);13541-8
[PubMed:15491161] [WorldCat.org] [DOI] (P p)

X Liu, H W Taber
Catabolite regulation of the Bacillus subtilis ctaBCDEF gene cluster.
J Bacteriol: 1998, 180(23);6154-63
[PubMed:9829923] [WorldCat.org] [DOI] (P p)

B Svensson, M Lübben, L Hederstedt
Bacillus subtilis CtaA and CtaB function in haem A biosynthesis.
Mol Microbiol: 1993, 10(1);193-201
[PubMed:7968515] [WorldCat.org] [DOI] (P p)