Difference between revisions of "CtaB"

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|style="background:#ABCDEF;" align="center"|'''Function''' || heme biosynthesis
 
|style="background:#ABCDEF;" align="center"|'''Function''' || heme biosynthesis
 
|-
 
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU14880 ctaB]
+
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU14880 ctaB]
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 33 kDa, 9.566   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 33 kDa, 9.566   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ctaA]]'', ''[[ctaC]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ctaA]]'', ''[[ctaC]]''
 
|-
 
|-
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB13361&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU14880 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU14880 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU14880 Advanced_DNA]
 
|-
 
|-
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ctaB_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ctaB_context.gif]]

Revision as of 12:44, 13 May 2013

  • Description: heme O synthase (major enzyme)

Gene name ctaB
Synonyms
Essential no
Product heme O synthase (major enzyme)
Function heme biosynthesis
Gene expression levels in SubtiExpress: ctaB
MW, pI 33 kDa, 9.566
Gene length, protein length 915 bp, 305 aa
Immediate neighbours ctaA, ctaC
Sequences Protein DNA Advanced_DNA
Genetic context
CtaB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CtaB expression.png
























Categories containing this gene/protein

biosynthesis of cofactors, membrane proteins

This gene is a member of the following regulons

ResD regulon

The gene

Basic information

  • Locus tag: BSU14880

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ubiA prenyltransferase family, Protoheme IX farnesyltransferase subfamily (according to Swiss-Prot)
  • Paralogous protein(s): CtaO

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • expressed under anaerobic conditions (ResD) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Tatsushi Mogi
Over-expression and characterization of Bacillus subtilis heme O synthase.
J Biochem: 2009, 145(5);669-75
[PubMed:19204012] [WorldCat.org] [DOI] (I p)

Brienne M Brown, Zhihong Wang, Kenneth R Brown, Julia A Cricco, Eric L Hegg
Heme O synthase and heme A synthase from Bacillus subtilis and Rhodobacter sphaeroides interact in Escherichia coli.
Biochemistry: 2004, 43(42);13541-8
[PubMed:15491161] [WorldCat.org] [DOI] (P p)

X Liu, H W Taber
Catabolite regulation of the Bacillus subtilis ctaBCDEF gene cluster.
J Bacteriol: 1998, 180(23);6154-63
[PubMed:9829923] [WorldCat.org] [DOI] (P p)

B Svensson, M Lübben, L Hederstedt
Bacillus subtilis CtaA and CtaB function in haem A biosynthesis.
Mol Microbiol: 1993, 10(1);193-201
[PubMed:7968515] [WorldCat.org] [DOI] (P p)