Difference between revisions of "CtaB"

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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:'''  
+
* '''Operon:''' ''[[ctaB]]-[[ctaC]]-[[ctaD]]-[[ctaE]]-[[ctaF]]-[[ctaG]]'' {{PubMed|9829923}}
  
 
* '''[[Sigma factor]]:'''  
 
* '''[[Sigma factor]]:'''  
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
** expressed under anaerobic conditions ([[ResD]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9829923 PubMed]
+
** expressed under anaerobic conditions ([[ResD]]) {{PubMed|9829923}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
** [[ResD]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/9829923 PubMed]
+
** [[ResD]]: transcription activation {{PubMed|9829923}}
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  

Revision as of 20:18, 8 October 2009

  • Description: heme O synthase (major enzyme)

Gene name ctaB
Synonyms
Essential no
Product heme O synthase (major enzyme)
Function heme biosynthesis
MW, pI 33 kDa, 9.566
Gene length, protein length 915 bp, 305 aa
Immediate neighbours ctaA, ctaC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CtaB context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU14880

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ubiA prenyltransferase family, Protoheme IX farnesyltransferase subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under anaerobic conditions (ResD) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Tatsushi Mogi
Over-expression and characterization of Bacillus subtilis heme O synthase.
J Biochem: 2009, 145(5);669-75
[PubMed:19204012] [WorldCat.org] [DOI] (I p)

Brienne M Brown, Zhihong Wang, Kenneth R Brown, Julia A Cricco, Eric L Hegg
Heme O synthase and heme A synthase from Bacillus subtilis and Rhodobacter sphaeroides interact in Escherichia coli.
Biochemistry: 2004, 43(42);13541-8
[PubMed:15491161] [WorldCat.org] [DOI] (P p)

X Liu, H W Taber
Catabolite regulation of the Bacillus subtilis ctaBCDEF gene cluster.
J Bacteriol: 1998, 180(23);6154-63
[PubMed:9829923] [WorldCat.org] [DOI] (P p)

B Svensson, M Lübben, L Hederstedt
Bacillus subtilis CtaA and CtaB function in haem A biosynthesis.
Mol Microbiol: 1993, 10(1);193-201
[PubMed:7968515] [WorldCat.org] [DOI] (P p)