CtaA

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  • Description: heme A synthase

Gene name ctaA
Synonyms
Essential no
Product heme A synthase
Function heme biosynthesis
Gene expression levels in SubtiExpress: ctaA
MW, pI 33 kDa, 9.644
Gene length, protein length 918 bp, 306 aa
Immediate neighbours pycA, ctaB
Sequences Protein DNA DNA_with_flanks
Genetic context
CtaA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CtaA expression.png
























Categories containing this gene/protein

biosynthesis of cofactors, sporulation proteins, membrane proteins

This gene is a member of the following regulons

ResD regulon, SigE regulon

The gene

Basic information

  • Locus tag: BSU14870

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: COX15/ctaA family, Type 1 subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under anaerobic conditions (ResD) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Tatsushi Mogi
Probing structure of heme A synthase from Bacillus subtilis by site-directed mutagenesis.
J Biochem: 2009, 145(5);625-33
[PubMed:19174544] [WorldCat.org] [DOI] (I p)

Anna Lewin, Lars Hederstedt
Promoted evolution of a shortened variant of heme A synthase in the membrane of Bacillus subtilis.
FEBS Lett: 2008, 582(9);1330-4
[PubMed:18358840] [WorldCat.org] [DOI] (P p)

Lars Hederstedt, Anna Lewin, Mimmi Throne-Holst
Heme A synthase enzyme functions dissected by mutagenesis of Bacillus subtilis CtaA.
J Bacteriol: 2005, 187(24);8361-9
[PubMed:16321940] [WorldCat.org] [DOI] (P p)

Matthew Schau, Amr Eldakak, F Marion Hulett
Terminal oxidases are essential to bypass the requirement for ResD for full Pho induction in Bacillus subtilis.
J Bacteriol: 2004, 186(24);8424-32
[PubMed:15576792] [WorldCat.org] [DOI] (P p)

Brienne M Brown, Zhihong Wang, Kenneth R Brown, Julia A Cricco, Eric L Hegg
Heme O synthase and heme A synthase from Bacillus subtilis and Rhodobacter sphaeroides interact in Escherichia coli.
Biochemistry: 2004, 43(42);13541-8
[PubMed:15491161] [WorldCat.org] [DOI] (P p)

S Paul, X Zhang, F M Hulett
Two ResD-controlled promoters regulate ctaA expression in Bacillus subtilis.
J Bacteriol: 2001, 183(10);3237-46
[PubMed:11325953] [WorldCat.org] [DOI] (P p)

X Zhang, F M Hulett
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
Mol Microbiol: 2000, 37(5);1208-19
[PubMed:10972837] [WorldCat.org] [DOI] (P p)

B Svensson, K K Andersson, L Hederstedt
Low-spin heme A in the heme A biosynthetic protein CtaA from Bacillus subtilis.
Eur J Biochem: 1996, 238(1);287-95
[PubMed:8665949] [WorldCat.org] [DOI] (P p)

B Svensson, L Hederstedt
Bacillus subtilis CtaA is a heme-containing membrane protein involved in heme A biosynthesis.
J Bacteriol: 1994, 176(21);6663-71
[PubMed:7961419] [WorldCat.org] [DOI] (P p)

B Svensson, M Lübben, L Hederstedt
Bacillus subtilis CtaA and CtaB function in haem A biosynthesis.
Mol Microbiol: 1993, 10(1);193-201
[PubMed:7968515] [WorldCat.org] [DOI] (P p)

J P Mueller, H W Taber
Structure and expression of the cytochrome aa3 regulatory gene ctaA of Bacillus subtilis.
J Bacteriol: 1989, 171(9);4979-86
[PubMed:2549007] [WorldCat.org] [DOI] (P p)