CsoR

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  • Description: transcription repressor of copZ-copA and of ycnJ

Gene name csoR
Synonyms yvgZ
Essential no
Product transcription repressor
Function control of copper homeostasis
MW, pI 11 kDa, 7.299
Gene length, protein length 303 bp, 101 aa
Immediate neighbours copZ, yvaA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvgZ context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU33520

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Genes controlled by CsoR

ycnJ PubMed

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Mohamed Marahiel, Marburg University, Germany homepage

Your additional remarks

References

Shashi Chillappagari, Andreas Seubert, Hein Trip, Oscar P Kuipers, Mohamed A Marahiel, Marcus Miethke
Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis.
J Bacteriol: 2010, 192(10);2512-24
[PubMed:20233928] [WorldCat.org] [DOI] (I p)

Zhen Ma, Darin M Cowart, Robert A Scott, David P Giedroc
Molecular insights into the metal selectivity of the copper(I)-sensing repressor CsoR from Bacillus subtilis.
Biochemistry: 2009, 48(15);3325-34
[PubMed:19249860] [WorldCat.org] [DOI] (I p)

Shashi Chillappagari, Marcus Miethke, Hein Trip, Oscar P Kuipers, Mohamed A Marahiel
Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis.
J Bacteriol: 2009, 191(7);2362-70
[PubMed:19168619] [WorldCat.org] [DOI] (I p)

Gregory T Smaldone, John D Helmann
CsoR regulates the copper efflux operon copZA in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 12);4123-4128
[PubMed:18048925] [WorldCat.org] [DOI] (P p)