Difference between revisions of "CsoR"

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(References)
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|style="background:#ABCDEF;" align="center"|'''Function''' || control of copper homeostasis
 
|style="background:#ABCDEF;" align="center"|'''Function''' || control of copper homeostasis
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU33520 csoR]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33520 csoR]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[copZ]]'', ''[[yvaA]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[copZ]]'', ''[[yvaA]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15357&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU33520 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU33520 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU33520 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:yvgZ_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yvgZ_context.gif]]

Revision as of 13:51, 13 May 2013

  • Description: transcription repressor of copZ-copA

Gene name csoR
Synonyms yvgZ
Essential no
Product transcription repressor
Function control of copper homeostasis
Gene expression levels in SubtiExpress: csoR
Metabolic function and regulation of this protein in SubtiPathways:
metal ion homeostasis
MW, pI 11 kDa, 7.299
Gene length, protein length 303 bp, 101 aa
Immediate neighbours copZ, yvaA
Sequences Protein DNA Advanced_DNA
Genetic context
YvgZ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CsoR expression.png















Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, resistance against toxic metals

This gene is a member of the following regulons

The CsoR regulon:

The gene

Basic information

  • Locus tag: BSU33520

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: Cu(I) ions cause release of CsoR from its operator sites

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Mohamed Marahiel, Marburg University, Germany homepage

Your additional remarks

References

Reviews

Corinna Rademacher, Bernd Masepohl
Copper-responsive gene regulation in bacteria.
Microbiology (Reading): 2012, 158(Pt 10);2451-2464
[PubMed:22918892] [WorldCat.org] [DOI] (I p)

Original publications

Shashi Chillappagari, Andreas Seubert, Hein Trip, Oscar P Kuipers, Mohamed A Marahiel, Marcus Miethke
Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis.
J Bacteriol: 2010, 192(10);2512-24
[PubMed:20233928] [WorldCat.org] [DOI] (I p)

Zhen Ma, Darin M Cowart, Robert A Scott, David P Giedroc
Molecular insights into the metal selectivity of the copper(I)-sensing repressor CsoR from Bacillus subtilis.
Biochemistry: 2009, 48(15);3325-34
[PubMed:19249860] [WorldCat.org] [DOI] (I p)

Shashi Chillappagari, Marcus Miethke, Hein Trip, Oscar P Kuipers, Mohamed A Marahiel
Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis.
J Bacteriol: 2009, 191(7);2362-70
[PubMed:19168619] [WorldCat.org] [DOI] (I p)

Gregory T Smaldone, John D Helmann
CsoR regulates the copper efflux operon copZA in Bacillus subtilis.
Microbiology (Reading): 2007, 153(Pt 12);4123-4128
[PubMed:18048925] [WorldCat.org] [DOI] (P p)