Difference between revisions of "CotU"

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(Extended information on the protein)
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* '''Regulation:'''  
 
* '''Regulation:'''  
** [[GerR]]: transcription repression {{PubMed|20435725}}
+
** expressed late during sporulation in the mother cell ([[SigK]], [[GerE]]) {{PubMed|18065538}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[GerE]]: transcription activation {{PubMed|18065538}}
 +
** [[GerR]]: transcription repression {{PubMed|20435725}}
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  

Revision as of 19:21, 31 July 2010

  • Description: spore coat protein

Gene name cotU
Synonyms ynzH
Essential no
Product spore coat protein
Function resistance of the spore
MW, pI 11 kDa, 6.315
Gene length, protein length 258 bp, 86 aa
Immediate neighbours yncF, thyA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YnzH context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU17670

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: the CotC-CotU complex assembles around the forming spore PubMed

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • expressed late during sporulation in the mother cell (SigK, GerE) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Giuseppina Cangiano, Antonio Mazzone, Loredana Baccigalupi, Rachele Isticato, Patrick Eichenberger, Maurilio De Felice, Ezio Ricca
Direct and indirect control of late sporulation genes by GerR of Bacillus subtilis.
J Bacteriol: 2010, 192(13);3406-13
[PubMed:20435725] [WorldCat.org] [DOI] (I p)

Rachele Isticato, Assunta Pelosi, Maurilio De Felice, Ezio Ricca
CotE binds to CotC and CotU and mediates their interaction during spore coat formation in Bacillus subtilis.
J Bacteriol: 2010, 192(4);949-54
[PubMed:20023017] [WorldCat.org] [DOI] (I p)

Rachele Isticato, Assunta Pelosi, Rita Zilhão, Loredana Baccigalupi, Adriano O Henriques, Maurilio De Felice, Ezio Ricca
CotC-CotU heterodimerization during assembly of the Bacillus subtilis spore coat.
J Bacteriol: 2008, 190(4);1267-75
[PubMed:18065538] [WorldCat.org] [DOI] (I p)

Erh-Min Lai, Nikhil D Phadke, Maureen T Kachman, Rebecca Giorno, Santiago Vazquez, Jenny A Vazquez, Janine R Maddock, Adam Driks
Proteomic analysis of the spore coats of Bacillus subtilis and Bacillus anthracis.
J Bacteriol: 2003, 185(4);1443-54
[PubMed:12562816] [WorldCat.org] [DOI] (P p)