CotR

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  • Description: spore protein, lipolytic enzyme

Gene name cotR
Synonyms yvdO
Essential no
Product spore lipolytic enzyme
Function hydrolysis of lysophospholipids
Gene expression levels in SubtiExpress: cotR
MW, pI 35 kDa, 10.2
Gene length, protein length 960 bp, 320 aa
Immediate neighbours cotQ, trnQ-Arg
Sequences Protein DNA Advanced_DNA
Genetic context
YvdO context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CotR expression.png
























Categories containing this gene/protein

utilization of lipids, sporulation proteins

This gene is a member of the following regulons

SigK regulon

The gene

Basic information

  • Locus tag: BSU34530

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: release of myristic acid from 1-myristoly-2-lyso-sn-glycero-3-phosphocholine PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • expressed late during sporulation in the mother cell (SigK) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Shiro Kato, Tohru Yoshimura, Hisashi Hemmi, Ryuichi Moriyama
Biochemical analysis of a novel lipolytic enzyme YvdO from Bacillus subtilis 168.
Biosci Biotechnol Biochem: 2010, 74(4);701-6
[PubMed:20378985] [WorldCat.org] [DOI] (I p)

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)

S Little, A Driks
Functional analysis of the Bacillus subtilis morphogenetic spore coat protein CotE.
Mol Microbiol: 2001, 42(4);1107-20
[PubMed:11737650] [WorldCat.org] [DOI] (P p)