copZ

168

copper transport protein, metallochaperone

locus: BSU_33510

Molecular weight: 7.20 kDa

pI: 4.16

Protein length: 69 aa

Gene length: 210 bp

function: resistance to copper

product: copper transport protein, metallochaperone

essential: no

synonyms: copZ, yvgY

List of homologs in different organisms, belongs to COG2608 (Galperin et al., 2021)

Gene

Coordinates: 3,443,613  3,443,822

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The protein

Catalyzed reaction/ biological activity

• transfers Cu(I) to [protein|727024F7B1AC19676ED4B516CF46A47B1328310B|copA] [Pubmed|28078344]

[wiki|Domains]

• HMA domain (aa 3-69) (according to UniProt)

[wiki|Cofactors]

• carries a tetranuclear Cu(I) cluster (as [Cu4(S-Cys)4(N-His)2] cluster) [Pubmed|19746989]

Structure

• [PDB|2QIF]
• [AF|O32221]

[wiki|Localization]

• cytoplasm (according to Swiss-Prot)

Biological materials

Mutant

• BKE33510 ([gene|18506FB74F6BB9278F22EB7DCDA3CF72575CC32A|copZ]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33510 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATCAATTCCTCCTGTTT,  downstream forward: _UP4_TGATTCAAGGTATCGCGCCT
• BKK33510 ([gene|18506FB74F6BB9278F22EB7DCDA3CF72575CC32A|copZ]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33510 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATCAATTCCTCCTGTTT,  downstream forward: _UP4_TGATTCAAGGTATCGCGCCT

labs

• [wiki|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

References

Reviews

• 19824702,10742187

Original Publications

• 18361527,11922674,12590580,14663075,12779235,12644235,18048925,19170606,14514665,14711369,15212800,19170606,19746989,19751213,18419582,22370900,12238948,11980486,27197762,28078344