Difference between revisions of "CopA"

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(Original publications)
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<pubmed> 19824702 </pubmed>
 
<pubmed> 19824702 </pubmed>
 
==Original publications==
 
==Original publications==
'''Additional publications:''' {{PubMed|22077885}}
+
'''Additional publications:''' {{PubMed|22531974,22077885}}
<pubmed>19751213 11922674,12590580,14663075,12779235,12644235,18048925,14514665,14711369, 19378562 15212800  20233928 22531974 </pubmed>
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<pubmed>19751213 11922674,12590580,14663075,12779235,12644235,18048925,14514665,14711369, 19378562 15212800  20233928 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 09:23, 27 April 2012

  • Description: copper-transporting ATPase, resistance to copper

Gene name copA
Synonyms yvgX
Essential no
Product copper transporting ATPase
Function copper export, detoxification
Interactions involving this protein in SubtInteract: CopA
Metabolic function and regulation of this protein in SubtiPathways:
metal ion homeostasis
MW, pI 85 kDa, 5.484
Gene length, protein length 2409 bp, 803 aa
Immediate neighbours cadA, copZ
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvgX context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CopA expression.png
























Categories containing this gene/protein

transporters/ other, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), resistance against toxic metals, membrane proteins

This gene is a member of the following regulons

CsoR regulon

The gene

Basic information

  • Locus tag: BSU33500

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + H2O + Cu1+(In) = ADP + phosphate + Cu1+(Out) (according to Swiss-Prot)
  • Protein family: Type IB subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
    • two N-terminal soluble domains, CopAa and CopAb, connected by a short linker
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2RML ( N-terminal soluble domain)
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Your additional remarks

References

Reviews

Amie K Boal, Amy C Rosenzweig
Structural biology of copper trafficking.
Chem Rev: 2009, 109(10);4760-79
[PubMed:19824702] [WorldCat.org] [DOI] (I p)

Original publications

Additional publications: PubMed