ComZ

• Description: late competence gene
  
  

Gene name	comZ
Synonyms	yjzA
Essential	no
Product	unknown
Function	compentence
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	7 kDa, 4.37
Gene length, protein length	189 bp, 63 aa
Immediate neighbours	med, yjzB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

genetic competence

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

• Locus tag: BSU11310

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O32437

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: med-comZ PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • Spo0A: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Virginie Molle, Masaya Fujita, Shane T Jensen, Patrick Eichenberger, José E González-Pastor, Jun S Liu, Richard Losick
The Spo0A regulon of Bacillus subtilis.
Mol Microbiol: 2003, 50(5);1683-701
[PubMed:14651647] [WorldCat.org] [DOI] (P p)

M Ogura, T Tanaka
Bacillus subtilis comZ (yjzA) negatively affects expression of comG but not comK.
J Bacteriol: 2000, 182(17);4992-4
[PubMed:10940045] [WorldCat.org] [DOI] (P p)

M Ogura, Y Ohshiro, S Hirao, T Tanaka
A new Bacillus subtilis gene, med, encodes a positive regulator of comK.
J Bacteriol: 1997, 179(20);6244-53
[PubMed:9335269] [WorldCat.org] [DOI] (P p)