ComN

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  • Description: mediates post-transcriptional control of comE operon expression

Gene name comN
Synonyms yrzD
Essential no
Product post-transcriptional regulator of comE expression
Function regulation of competence and DNA uptake
Interactions involving this protein in SubtInteract: ComN
MW, pI 11 kDa, 4.622
Gene length, protein length 294 bp, 98 aa
Immediate neighbours secDF, spoVB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YrzD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ComN expression.png















Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

The ComN regulon: comEA-comEB-comEC

The gene

Basic information

  • Locus tag: BSU27660

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • post-transcriptional control of comEA expression PubMed
    • promotes the accumulation of its target comEA mRNA to septal and polar sites PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Valquiria Tiago dos Santos, Alexandre W Bisson-Filho, Frederico J Gueiros-Filho
DivIVA-mediated polar localization of ComN, a posttranscriptional regulator of Bacillus subtilis.
J Bacteriol: 2012, 194(14);3661-9
[PubMed:22582279] [WorldCat.org] [DOI] (I p)

Mitsuo Ogura, Teruo Tanaka
The Bacillus subtilis late competence operon comE is transcriptionally regulated by yutB and under post-transcription initiation control by comN (yrzD).
J Bacteriol: 2009, 191(3);949-58
[PubMed:19028902] [WorldCat.org] [DOI] (I p)