Difference between revisions of "ComK"

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{{SubtiWiki regulon|[[DegU regulon]]}},
 
{{SubtiWiki regulon|[[DegU regulon]]}},
 
{{SubtiWiki regulon|[[Rok regulon]]}}
 
{{SubtiWiki regulon|[[Rok regulon]]}}
 
+
=The [[ComK regulon]]=
 
=The gene=
 
=The gene=
  
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==Reviews==
 
==Reviews==
 
<pubmed>19995980 12576575 </pubmed>
 
<pubmed>19995980 12576575 </pubmed>
 +
==The [[ComK regulon]]==
 +
<pubmed>11948146,11918817,</pubmed>
 
==Original Publications==
 
==Original Publications==
<pubmed>8878039,11849533,17569828,9335269,8016067,17493123,17560370,12586407,11814663,9108277,9890793,9585513,11948146,15819619,10908654,9000055,7783616,7746142,11918817,11849533,8830686,12586407, 10447896, 12028382, 8016067, 10361283, 11703662, 12107147, 17581123, 8016066 17493123,16391071,16436435 12270822 15598897 20300532 12761164 12036071 21085679 </pubmed>
+
<pubmed>8878039,11849533,17569828,9335269,8016067,17493123,17560370,12586407,11814663,9108277,9890793,9585513,15819619,10908654,9000055,7783616,7746142,8830686,12586407, 10447896, 12028382, 8016067, 10361283, 11703662, 12107147, 17581123, 8016066 17493123,16391071,16436435 12270822 15598897 20300532 12761164 12036071 21085679 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 10:29, 12 December 2010

  • Description: competence transcription factor (CTF)

Gene name comK
Synonyms
Essential no
Product competence transcription factor (CTF)
Function regulation of competence and DNA uptake
Metabolic function and regulation of this protein in SubtiPathways:
Nucleotides (regulation), Protein secretion
MW, pI 22 kDa, 7.669
Gene length, protein length 576 bp, 192 aa
Immediate neighbours yhzC, yhxD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComK context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

genetic competence, transcription factors and their control

This gene is a member of the following regulons

AbrB regulon, CodY regulon, ComK regulon, DegU regulon, Rok regulon

The ComK regulon

The gene

Basic information

  • Locus tag: BSU10420

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by casamino acids PubMed
    • repressed by Rok PubMed
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
    • repressed during logrithmic growth (AbrB) PubMed
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Oscar Kuipers, University of Groningen, The Netherlands Homepage

Your additional remarks

References

Reviews

Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21027-34
[PubMed:19995980] [WorldCat.org] [DOI] (I p)

Leendert W Hamoen, Gerard Venema, Oscar P Kuipers
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading): 2003, 149(Pt 1);9-17
[PubMed:12576575] [WorldCat.org] [DOI] (P p)

The ComK regulon

Original Publications