Difference between revisions of "ComGC"

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* '''Description:''' DNA uptake, major component of the pseudopilus <br/><br/>
+
* '''Description:''' DNA uptake, major component of the [[pseudopilus]] <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || no  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || major component of the pseudopilus
+
|style="background:#ABCDEF;" align="center"| '''Product''' || major pseudopilin
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Function''' || [[genetic competence]]
 
|style="background:#ABCDEF;" align="center"|'''Function''' || [[genetic competence]]
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=== Additional information===
 
=== Additional information===
 
 
 
  
 
=The protein=
 
=The protein=
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* '''Interactions:'''
 
* '''Interactions:'''
** forms large complexes (the pseudopilus) {{PubMed|21278288}}
+
** [[ComGB]]-[[ComGC]] {{PubMed|15083159}}
 +
** forms large complexes (the [[pseudopilus]]) {{PubMed|21278288}}
  
 
* '''Localization:'''  
 
* '''Localization:'''  
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=References=
 
=References=
 
+
==Reviews==
 +
<pubmed> 15083159 </pubmed>
 +
==Original publications==
 
<pubmed>11744713,11814663,9422590,16751195,9723928,1968455,7783624,21278288,12107147, 2507524 8196543</pubmed>
 
<pubmed>11744713,11814663,9422590,16751195,9723928,1968455,7783624,21278288,12107147, 2507524 8196543</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 15:04, 8 April 2011

  • Description: DNA uptake, major component of the pseudopilus

Gene name comGC
Synonyms
Essential no
Product major pseudopilin
Function genetic competence
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 10 kDa, 6.325
Gene length, protein length 294 bp, 98 aa
Immediate neighbours comGD, comGB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComGC context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

  • Locus tag: BSU24710

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: comGC family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):

=

  • Effectors of protein activity:
  • Localization:
    • cell surface PubMed
    • localizes to the cell membrane and the cytoplasm PubMed
    • localizes to one single cell pole in the majority of the cells PubMed

= Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed by casamino acids PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159] [WorldCat.org] [DOI] (P p)

Original publications