ComEA

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  • Description: membrane DNA receptor, plays an important role in the transfer of transforming DNA into the DNA channel and in controlling the rate of DNA uptake

Gene name comEA
Synonyms comD
Essential no
Product membrane DNA receptor
Function genetic competence
Interactions involving this protein in SubtInteract: ComEA
Metabolic function and regulation of this protein in SubtiPathways:
Nucleotides (regulation), Protein secretion
MW, pI 21 kDa, 4.824
Gene length, protein length 615 bp, 205 aa
Immediate neighbours comEB, comER
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComEA context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

genetic competence, membrane proteins

This gene is a member of the following regulons

ComK regulon, ComN regulon

The gene

Basic information

  • Locus tag: BSU25590

Phenotypes of a mutant

  • strongly reduced transformation rate PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2DUY (from Thermus thermophilus hb8, 37% identity, 60% similarity)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159] [WorldCat.org] [DOI] (P p)

Original publications