Difference between revisions of "ComEA"
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| − | * '''Description:''' membrane DNA receptor <br/><br/> | + | * '''Description:''' membrane DNA receptor, plays an important role in the transfer of transforming DNA into the DNA channel and in controlling the rate of DNA uptake <br/><br/> |
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * strongly reduced transformation rate {{PubMed|22398145}} | ||
=== Database entries === | === Database entries === | ||
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<pubmed> 15083159 </pubmed> | <pubmed> 15083159 </pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed>9987128,11814663,7768800,16751195,7968523,17630974, 21278288,19028902, 21707789 </pubmed> | + | <pubmed>9987128,11814663,7768800,16751195,7968523,17630974, 21278288,19028902, 21707789 22398145</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 19:18, 14 March 2012
- Description: membrane DNA receptor, plays an important role in the transfer of transforming DNA into the DNA channel and in controlling the rate of DNA uptake
| Gene name | comEA |
| Synonyms | comD |
| Essential | no |
| Product | membrane DNA receptor |
| Function | genetic competence |
| Interactions involving this protein in SubtInteract: ComEA | |
| Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation), Protein secretion | |
| MW, pI | 21 kDa, 4.824 |
| Gene length, protein length | 615 bp, 205 aa |
| Immediate neighbours | comEB, comER |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
genetic competence, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU25590
Phenotypes of a mutant
- strongly reduced transformation rate PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cell membrane, no distinct position PubMed
Database entries
- Structure: 2DUY (from Thermus thermophilus hb8, 37% identity, 60% similarity)
- UniProt: P39694
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159]
[WorldCat.org]
[DOI]
(P p)
Original publications
