ComA

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  • Description: two-component system response regulator, controls gene expression in response to cell density (concentration of ComX)

Gene name comA
Synonyms srfB, comAA
Essential no
Product two-component system response regulator
Function regulation of genetic competence and quorum sensing
MW, pI 23 kDa, 4.759
Gene length, protein length 642 bp, 214 aa
Immediate neighbours yuxO, comP
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComA context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

genetic competence, transcription factors and their control, quorum sensing, phosphoproteins

This gene is a member of the following regulons

The ComA regulon

The gene

Basic information

  • Locus tag: BSU31680

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ComA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated by ComP on an Asp residue
  • Cofactor(s):
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Daniel López, Roberto Kolter
Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis.
FEMS Microbiol Rev: 2010, 34(2);134-49
[PubMed:20030732] [WorldCat.org] [DOI] (I p)

Leendert W Hamoen, Gerard Venema, Oscar P Kuipers
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading): 2003, 149(Pt 1);9-17
[PubMed:12576575] [WorldCat.org] [DOI] (P p)


Original Publications