CdaS

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  • Description: sporulation-specific diadenylate cyclase, synthesis of c-di-AMP

Gene name cdaS
Synonyms yojJ
Essential no
Product sporulation-specific diadenylate cyclase
Function synthesis of c-di-AMP
Gene expression levels in SubtiExpress: cdaS
MW, pI 22 kDa, 5.367
Gene length, protein length 621 bp, 207 aa
Immediate neighbours yojK, yojI
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YojJ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YojJ expression.png















Categories containing this gene/protein

metabolism of signalling nucleotides, sporulation proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU19430

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • synthesis of c-di-AMP from two molecules of ATP PubMed
  • Protein family:
  • Paralogous protein(s): CdaA

Extended information on the protein

  • Kinetic information:
  • Domains: contains a DAC domain involved in the synthesis of c-di-AMP PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2FB5 (the protein of B. cereus, 48% identity, 81% similarity)
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed late during sporulation in the forespore (SigG) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Ute Römling
Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.
Sci Signal: 2008, 1(33);pe39
[PubMed:18714086] [WorldCat.org] [DOI] (I e)

Original publications