Difference between revisions of "CcpA"

From SubtiWiki
Jump to: navigation, search
(Basic information/ Evolution)
(Extended information on the protein)
Line 69: Line 69:
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''Cofactor(s):''' HPr-Ser46-P, Crh-Ser-46-P
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:''' CcpA-[[PtsH]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12432959 PubMed], CcpA-[[Crh]]
+
* '''Interactions:''' CcpA-[[PtsH]] [http://www.ncbi.nlm.nih.gov/pubmed/15369672?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum PubMed], CcpA-[[Crh]]
  
 
* '''Localization:'''
 
* '''Localization:'''

Revision as of 16:58, 6 January 2009

  • Description: carbon catabolite control protein A, involved in glucose regulation of many genes; mediates carbon catabolite repression (CCR)of catabolic genes and the positive regulation of genes involved in excretion of excess carbon

Gene name ccpA
Synonyms graR, alsA, amyR
Essential no
Product transcriptional regulator
Function mediates carbon catabolite repression (CCR)
MW, pI 36,8 kDa, 5.06
Gene length, protein length 1002 bp, 334 amino acids
Immediate neighbours aroA, motP
Gene sequence (+200bp) Protein sequence
Genetic context
File:GenE context.gif












The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transcriptional regulator of carbon catabolite repression (CCR)
  • Protein family: LacI family
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
    • HTH lacI-type Domain (1 – 58)
    • DNA binding Domain (6 – 25)
  • Modification:
  • Cofactor(s): HPr-Ser46-P, Crh-Ser-46-P
  • Effectors of protein activity:
  • Localization:

Database entries

  • Swiss prot entry: [3]
  • KEGG entry: [4]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed
  2. Terahara et al. (2006) An intergenic stem-loop mutation in the Bacillus subtilis ccpA-motPS operon increases motPS transcription and the MotPS contribution to motility J Bacteriol. 188(7): 2701-5. PubMed
  3. Mahr K, Esteban CD & Hillen W (2002) Cross communication between components of carbon catabolite repression of Lactobacillus casei and Bacillus megaterium J Mol Microbiol Biotechnol. 4(5): 489-94. PubMed
  4. Juy M, Penin F, Favier A (2003) Dimerization of Crh by reversible 3D domain swapping induces structural adjustments to its monomeric homologue Hpr. J Mol Biol. 332(4):767-76. PubMed