Difference between revisions of "CarB"

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* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P18185 P18185]
 
* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P18185 P18185]
  
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU11240]
+
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU11240]
  
 
* '''E.C. number:''' [http://www.expasy.org/enzyme/6.3.5.5 6.3.5.5]
 
* '''E.C. number:''' [http://www.expasy.org/enzyme/6.3.5.5 6.3.5.5]

Revision as of 01:25, 25 June 2009

  • Description: carbamoyl-phosphate transferase-arginine subunit B)

Gene name carB
Synonyms cpa
Essential no
Product carbamoyl-phosphate transferase-arginine subunit B)
Function biosynthesis of arginine
Metabolic function and regulation of this protein in SubtiPathways:
Pyrimidines, Ammonium/ glutamate
MW, pI 112 kDa, 4.712
Gene length, protein length 3090 bp, 1030 aa
Immediate neighbours carA, argF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
CarB context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU11240

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate (according to Swiss-Prot)
  • Protein family: carB family (according to Swiss-Prot)
  • Paralogous protein(s): PyrAB

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Regulation: repressed by casamino acids PubMed, repressed by arginine (AhrC)
  • Regulatory mechanism: AhrC: transcription repression
  • Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References