Difference between revisions of "CadA"

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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33490 cadA]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU33490 cadA]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://cellpublisher.gobics.de/view/GqbblRJkBH metal ion homeostasis]'''
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=CadA CadA]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 75 kDa, 5.998   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 75 kDa, 5.998   

Revision as of 11:53, 8 April 2014

  • Description: cadmium transporting ATPase, resistance to cadmium

Gene name cadA
Synonyms yvgW
Essential no
Product cadmium transporting ATPase
Function cadmium export
Gene expression levels in SubtiExpress: cadA
Metabolic function and regulation of this protein in SubtiPathways:
CadA
MW, pI 75 kDa, 5.998
Gene length, protein length 2106 bp, 702 aa
Immediate neighbours bdbD, copA
Sequences Protein DNA DNA_with_flanks
Genetic context
YvgW context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CadA expression.png















Categories containing this gene/protein

transporters/ other, resistance against toxic metals, membrane proteins

This gene is a member of the following regulons

CzrA regulon

The gene

Basic information

  • Locus tag: BSU33490

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out) (according to Swiss-Prot)
  • Protein family: Type IB subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
    • ** 4BBJ (CopA from Legionella pneumophila, 32% identity, 67% similarity) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation:
    • induced by toxic metal ions (Zn(II), Cd(II), Co(II), Ni(II) and Cu(II)) (CzrA) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Your additional remarks

References