Difference between revisions of "CadA"
| Line 37: | Line 37: | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
| − | |||
| − | |||
| − | |||
| − | |||
<br/><br/> | <br/><br/> | ||
| Line 66: | Line 62: | ||
=== Additional information=== | === Additional information=== | ||
| − | |||
| − | |||
| − | |||
=The protein= | =The protein= | ||
| Line 84: | Line 77: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| Line 99: | Line 92: | ||
* '''Structure:''' | * '''Structure:''' | ||
| + | ** ** [http://www.pdb.org/pdb/explore/explore.do?structureId=4BBJ 4BBJ] (CopA from ''Legionella pneumophila'', 32% identity, 67% similarity) {{PubMed|24317491}} | ||
* '''UniProt:''' [http://www.uniprot.org/uniprot/O32219 O32219] | * '''UniProt:''' [http://www.uniprot.org/uniprot/O32219 O32219] | ||
| Line 145: | Line 139: | ||
=References= | =References= | ||
| − | <pubmed>15948947,12779235,,11934502 , </pubmed> | + | <pubmed>15948947,12779235,24317491,11934502 , </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 14:34, 8 January 2014
- Description: cadmium transporting ATPase, resistance to cadmium
| Gene name | cadA |
| Synonyms | yvgW |
| Essential | no |
| Product | cadmium transporting ATPase |
| Function | cadmium export |
| Gene expression levels in SubtiExpress: cadA | |
| Metabolic function and regulation of this protein in SubtiPathways: metal ion homeostasis | |
| MW, pI | 75 kDa, 5.998 |
| Gene length, protein length | 2106 bp, 702 aa |
| Immediate neighbours | bdbD, copA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transporters/ other, resistance against toxic metals, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU33490
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out) (according to Swiss-Prot)
- Protein family: Type IB subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- UniProt: O32219
- KEGG entry: [2]
- E.C. number: 3.6.3.3
Additional information
Expression and regulation
- Operon: cadA PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Magnus Andersson, Daniel Mattle, Oleg Sitsel, Tetyana Klymchuk, Anna Marie Nielsen, Lisbeth Birk Møller, Stephen H White, Poul Nissen, Pontus Gourdon
Copper-transporting P-type ATPases use a unique ion-release pathway.
Nat Struct Mol Biol: 2014, 21(1);43-8
[PubMed:24317491]
[WorldCat.org]
[DOI]
(I p)
Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947]
[WorldCat.org]
[DOI]
(P p)
Ahmed Gaballa, John D Helmann
Bacillus subtilis CPx-type ATPases: characterization of Cd, Zn, Co and Cu efflux systems.
Biometals: 2003, 16(4);497-505
[PubMed:12779235]
[WorldCat.org]
[DOI]
(P p)
I M Solovieva, K D Entian
Investigation of the yvgW Bacillus subtilis chromosomal gene involved in Cd(2+) ion resistance.
FEMS Microbiol Lett: 2002, 208(1);105-9
[PubMed:11934502]
[WorldCat.org]
[DOI]
(P p)
