Difference between revisions of "BshC"

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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of bacillithiol
 
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of bacillithiol
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU15120 bshC]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU15120 bshC]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 62 kDa, 5.247   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 62 kDa, 5.247   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ylbQ]]'', ''[[mraZ]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ylbQ]]'', ''[[mraZ]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB13385&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU15120 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU15120 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU15120 Advanced_DNA]
 
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Revision as of 12:45, 13 May 2013

  • Description: cysteine-adding enzyme required for the synthesis of bacillithiol

Gene name bshC
Synonyms yllA
Essential no
Product cysteine-adding enzyme
Function biosynthesis of bacillithiol
Gene expression levels in SubtiExpress: bshC
MW, pI 62 kDa, 5.247
Gene length, protein length 1617 bp, 539 aa
Immediate neighbours ylbQ, mraZ
Sequences Protein DNA Advanced_DNA
Genetic context
YllA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
BshC expression.png


























Categories containing this gene/protein

miscellaneous metabolic pathways, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU15120

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541] [WorldCat.org] [DOI] (I p)

Gerald L Newton, Mamta Rawat, James J La Clair, Vishnu Karthik Jothivasan, Tanya Budiarto, Chris J Hamilton, Al Claiborne, John D Helmann, Robert C Fahey
Bacillithiol is an antioxidant thiol produced in Bacilli.
Nat Chem Biol: 2009, 5(9);625-7
[PubMed:19578333] [WorldCat.org] [DOI] (I p)

R A Daniel, A M Williams, J Errington
A complex four-gene operon containing essential cell division gene pbpB in Bacillus subtilis.
J Bacteriol: 1996, 178(8);2343-50
[PubMed:8636036] [WorldCat.org] [DOI] (P p)