Difference between revisions of "BshC"

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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:''' ''[[yllA]]'' {{PubMed|8636036}}
+
* '''Operon:''' ''[[ylbQ]]-[[bshC]]'' {{PubMed|20308541}}
  
 
* '''[[Sigma factor]]:'''  
 
* '''[[Sigma factor]]:'''  
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=References=
 
=References=
<pubmed> 8636036 20308541</pubmed>
+
<pubmed> 8636036 20308541 19578333 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 15:22, 7 April 2010

  • Description: cysteine-adding enzyme required for the synthesis of bacillithiol

Gene name bshC
Synonyms yllA
Essential no
Product cysteine-adding enzyme
Function biosynthesis of bacillithiol
MW, pI 62 kDa, 5.247
Gene length, protein length 1617 bp, 539 aa
Immediate neighbours ylbQ, mraZ
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YllA context.gif
This image was kindly provided by SubtiList





The gene

Basic information

  • Locus tag: BSU15120

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541] [WorldCat.org] [DOI] (I p)

Gerald L Newton, Mamta Rawat, James J La Clair, Vishnu Karthik Jothivasan, Tanya Budiarto, Chris J Hamilton, Al Claiborne, John D Helmann, Robert C Fahey
Bacillithiol is an antioxidant thiol produced in Bacilli.
Nat Chem Biol: 2009, 5(9);625-7
[PubMed:19578333] [WorldCat.org] [DOI] (I p)

R A Daniel, A M Williams, J Errington
A complex four-gene operon containing essential cell division gene pbpB in Bacillus subtilis.
J Bacteriol: 1996, 178(8);2343-50
[PubMed:8636036] [WorldCat.org] [DOI] (P p)