BrxA

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  • Description: disulfide isomerase, bacilliredoxin

Gene name brxA
Synonyms yphP
Essential no
Product disulfide isomerase, bacilliredoxin
Function de-bacillithiolation of S-bacillithiolated OhrR and MetE
Gene expression levels in SubtiExpress: yphP
MW, pI 15 kDa, 4.619
Gene length, protein length 432 bp, 144 aa
Immediate neighbours ypiP, ilvD
Sequences Protein DNA DNA_with_flanks
Genetic context
YphP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YphP expression.png















Categories containing this gene/protein

poorly characterized/ putative enzymes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU21860

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: scpA family (according to Swiss-Prot)
  • Paralogous protein(s): yqiW

Extended information on the protein

  • Kinetic information:
  • Domains: contains an CxC redox motif [3]
  • Modification:
    • S-bacillithiolation upon hypochlorite stress on Cys-53 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [4]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: yphP (according to DBTBS)
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

YpdA, YqiW, YphP and YtxJ co-occur in those species predicted to synthesize bacillithiol.

References