BmrU

• Description: general stress protein, multidrug resistance protein, similar to diacylglycerol kinase
  
  

Gene name	bmrU
Synonyms
Essential	no
Product	multidrug resistance protein
Function	multidrug resistance
MW, pI	32 kDa, 5.393
Gene length, protein length	891 bp, 297 aa
Immediate neighbours	yqiW, bmr
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

general stress proteins (controlled by SigB), resistance against toxins/ antibiotics

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

• Locus tag: BSU24000

Expression

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): DgkB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3S40 (from B. anthracis, 39% identity, 73% similarity)

• UniProt: P39074

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: bmrU-bmr-bmrR PubMed

• Sigma factor: SigB PubMed

• Regulation:
  • induced by stress (SigB) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)

Anja Petersohn, Haike Antelmann, Ulf Gerth, Michael Hecker
Identification and transcriptional analysis of new members of the sigmaB regulon in Bacillus subtilis.
Microbiology (Reading): 1999, 145 ( Pt 4);869-880
[PubMed:10220166] [WorldCat.org] [DOI] (P p)