BmrD

• Description: multidrug ABC transporter (ATP-binding protein), also involved in the signalling pathway to activate KinA at the onset of sporulation
  
  

Gene name	bmrD
Synonyms	yheH
Essential	no
Product	multidrug ABC transporter (ATP-binding protein)
Function	multiple antibiotic resistance
Gene expression levels in SubtiExpress: bmrD
Interactions involving this protein in SubtInteract: BmrD
MW, pI	76 kDa, 7.082
Gene length, protein length	2019 bp, 673 aa
Immediate neighbours	bmrC, yheG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics, membrane proteins

The gene

Basic information

• Locus tag: BSU09720

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: has both a membrane-spanning and an ATP-binding domain PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • BmrC-BmrD PubMed

• Localization: cell membrane PubMed

Database entries

• Structure:

• UniProt: O07549

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: bmrD PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Cristina Torres, Carmen Galián, Christoph Freiberg, Jean-Raphaël Fantino, Jean-Michel Jault
The YheI/YheH heterodimer from Bacillus subtilis is a multidrug ABC transporter.
Biochim Biophys Acta: 2009, 1788(3);615-22
[PubMed:19167342] [WorldCat.org] [DOI] (P p)

Sanae Fukushima, Mika Yoshimura, Taku Chibazakura, Tsutomu Sato, Hirofumi Yoshikawa
The putative ABC transporter YheH/YheI is involved in the signalling pathway that activates KinA during sporulation initiation.
FEMS Microbiol Lett: 2006, 256(1);90-7
[PubMed:16487324] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)