Difference between revisions of "BmrD"
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' | + | * '''Operon:''' ''[[bmrB]]-[[bmrC]]-[[bmrD]]'' {{PubMed|25217586}} |
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yheH_1047072_1049093_1 bmrD] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yheH_1047072_1049093_1 bmrD] {{PubMed|22383849}} | ||
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* '''Regulation:''' | * '''Regulation:''' | ||
| + | ** induced in response to antibiotics that target protein synthesis ([[BmrB]]) {{PubMed|25217586}} | ||
| + | ** ''[[bmrC]]-[[bmrD]]'' expression only occurs during the late-exponential and stationary growth stages, irrespective of the timing of the antibiotic challenge ([[AbrB]]) {{PubMed|25217586}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[AbrB]]: transcription repression {{PubMed|25217586}} | ||
| + | ** [[BmrB]]: transcriptional attenuation {{PubMed|25217586}} | ||
* '''Additional information:''' | * '''Additional information:''' | ||
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=References= | =References= | ||
| − | + | <pubmed>19167342,10092453,16487324 25217586 21602923</pubmed> | |
| − | <pubmed>19167342,10092453,16487324</pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 08:43, 19 September 2014
- Description: multidrug ABC transporter (ATP-binding protein), also involved in the signalling pathway to activate KinA at the onset of sporulation
| Gene name | bmrD |
| Synonyms | yheH |
| Essential | no |
| Product | multidrug ABC transporter (ATP-binding protein) |
| Function | multiple antibiotic resistance |
| Gene expression levels in SubtiExpress: bmrD | |
| Interactions involving this protein in SubtInteract: BmrD | |
| MW, pI | 76 kDa, 7.082 |
| Gene length, protein length | 2019 bp, 673 aa |
| Immediate neighbours | bmrC, yheG |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
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Contents
Categories containing this gene/protein
ABC transporters, resistance against toxins/ antibiotics, membrane proteins, sporulation proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU09720
Phenotypes of a mutant
Database entries
- BsubCyc: BSU09720
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: has both a membrane-spanning and an ATP-binding domain PubMed
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane PubMed
Database entries
- BsubCyc: BSU09720
- Structure:
- UniProt: O07549
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ewoud Reilman, Ruben A T Mars, Jan Maarten van Dijl, Emma L Denham
The multidrug ABC transporter BmrC/BmrD of Bacillus subtilis is regulated via a ribosome-mediated transcriptional attenuation mechanism.
Nucleic Acids Res: 2014, 42(18);11393-407
[PubMed:25217586]
[WorldCat.org]
[DOI]
(I p)
Carmen Galián, Florence Manon, Manuela Dezi, Cristina Torres, Christine Ebel, Daniel Lévy, Jean-Michel Jault
Optimized purification of a heterodimeric ABC transporter in a highly stable form amenable to 2-D crystallization.
PLoS One: 2011, 6(5);e19677
[PubMed:21602923]
[WorldCat.org]
[DOI]
(I p)
Cristina Torres, Carmen Galián, Christoph Freiberg, Jean-Raphaël Fantino, Jean-Michel Jault
The YheI/YheH heterodimer from Bacillus subtilis is a multidrug ABC transporter.
Biochim Biophys Acta: 2009, 1788(3);615-22
[PubMed:19167342]
[WorldCat.org]
[DOI]
(P p)
Sanae Fukushima, Mika Yoshimura, Taku Chibazakura, Tsutomu Sato, Hirofumi Yoshikawa
The putative ABC transporter YheH/YheI is involved in the signalling pathway that activates KinA during sporulation initiation.
FEMS Microbiol Lett: 2006, 256(1);90-7
[PubMed:16487324]
[WorldCat.org]
[DOI]
(P p)
Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453]
[WorldCat.org]
[DOI]
(P p)
