bmrA

168

multidrug [wiki|ABC transporter] (ATP-binding protein)

locus: BSU_34820

Molecular weight: 64.34 kDa

pI: 6.47

Protein length: 589 aa

Gene length: 1770 bp

function: multiple antibiotic resistance

product: multidrug [wiki|ABC transporter] (ATP-binding protein)

essential: no

synonyms: bmrA, yvcC

List of homologs in different organisms, belongs to COG1132 (Galperin et al., 2021)

Gene

Coordinates: 3,577,745 → 3,579,514

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The protein

Protein family

• [wiki|ABC transporter superfamily] (according to UniProt)

[wiki|Domains]

• has both a membrane-spanning and an ATP-binding domain [Pubmed|10092453]
• [wiki|ABC transmembrane type-1 domain] (aa 29-309) (according to UniProt)
• [wiki|ABC transporter domain] (aa 341-576) (according to UniProt)

Structure

• [PDB|6R72] [pubmed|35080979]
• [AF|O06967]

Paralogous protein(s)

• [protein|70D7098BEBD5E53B4B9B8C3394FAAF972C65EE22|yknU], [protein|E85814EDF232D21A42380D559EAD2CDFB41F19DB|yfiC], [protein|D5A3C316BD4567A0155F70330E32ACDE18F063FE|ywjA], [protein|C6B0ACB9D9703DD8141FD7D9D62DB22FB48F458B|yknV], [protein|0EB4D3E1B9AF39ECCBD79EB559FAE5BB0EE4C156|ygaD], [protein|288CA73D93B1E5106E1C6CE5E7E2E8BE2A6BD3F3|yfiB], [protein|67C0C9EA17EF953554D3D57CD0D285246F50C1AD|bmrC]

[wiki|Localization]

• membrane [Pubmed|10092453]

Biological materials

Mutant

• MGNA-B645 (yvcC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1644 NBRP B. subtilis, Japan]
• BKE34820 (Δ[gene|ED1F82463BAA28B67184BFAB5CB23CF26A62999D|bmrA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE34820 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATATTTTCCTCCTGTTT,  downstream forward: _UP4_TAAATTTTGGTCGAATCAGC
• BKK34820 (Δ[gene|ED1F82463BAA28B67184BFAB5CB23CF26A62999D|bmrA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK34820 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATATTTTCCTCCTGTTT,  downstream forward: _UP4_TAAATTTTGGTCGAATCAGC

References

Reviews

• 33450852

Original Publications

• 16107340,15182191,15766260,16405427,12968023,10092453,18215075,12225846,20544182,11827477,21077936,21336797,21483854,27570617,28755379,29662596,23716676,24630999,31044174,31924974,33198135,33212311,34948362,34988902,35080979,38072053