BkdB

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  • Description: 2-oxoisovalerate dehydrogenase (E2 subunit, lipoamide acyltransferase)

Gene name bkdB
Synonyms bfmBB, bfmB2, bkd
Essential no
Product 2-oxoisovalerate dehydrogenase
(E2 subunit, lipoamide acyltransferase)
Function utilization of branched-chain keto acids
Gene expression levels in SubtiExpress: bkdB
Metabolic function and regulation of this protein in SubtiPathways:
bkdB
MW, pI 45 kDa, 5.301
Gene length, protein length 1272 bp, 424 aa
Immediate neighbours bmrR, bkdAB
Sequences Protein DNA DNA_with_flanks
Genetic context
BkdB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
BkdB expression.png















Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

BkdR regulon, CodY regulon, SigL regulon

The gene

Basic information

  • Locus tag: BSU24030

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2-methylpropanoyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-(2-methylpropanoyl)dihydrolipoyl)lysine (according to Swiss-Prot)
  • Protein family: 2-oxoacid dehydrogenase family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
    • lipoic acid
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • induced in the presence of isoleucine or valine (BkdR) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References