Difference between revisions of "BkdAB"

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* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/10094682 PubMed]
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10094682 PubMed]
  
 
* '''Additional information:'''
 
* '''Additional information:'''

Revision as of 11:50, 11 June 2009

  • Description: 2-oxoisovalerate dehydrogenase (E1 beta subunit)

Gene name bkdAB
Synonyms bfmBAB, bfmB1b, bkd
Essential no
Product 2-oxoisovalerate dehydrogenase (E1 beta subunit)

(2-oxoisovalerate dehydrogenase beta subunit) (EC 1.2.4.4)

Function utilization of branched-chain keto acids
MW, pI 35 kDa, 4.791
Gene length, protein length 981 bp, 327 aa
Immediate neighbours bkdB, bkdAA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
BkdAB context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU24040

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: Cytoplasm (Homogeneous) PubMed

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References


  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed