Biosynthesis of cofactors

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Genes in this functional category

Biosynthesis/ acquisition of biotin

Biosynthesis/ acquisition of riboflavin/ fad

Biosynthesis/ acquisition of thiamine

Biosynthesis of coenzyme a

Biosynthesis of folate

Biosynthesis of heme/ siroheme

Biosynthesis of lipoic acid (For complete biosynthetic pathway see PubMed)

Biosynthesis of menaquinone

Biosynthesis of menaquinone/ based on similarity

Biosynthesis of molybdopterin

Biosynthesis of nad(p)

Biosynthesis of pyridoxal phosphate

Metabolism of cofactors in SubtiPathways

Important reviews

Additional reviews: PubMed

Tadhg P Begley, Steven E Ealick, Fred W McLafferty
Thiamin biosynthesis: still yielding fascinating biological chemistry.
Biochem Soc Trans: 2012, 40(3);555-60
[PubMed:22616866] [WorldCat.org] [DOI] (I p)

Christopher T Jurgenson, Tadhg P Begley, Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annu Rev Biochem: 2009, 78;569-603
[PubMed:19348578] [WorldCat.org] [DOI] (I p)

Tadhg P Begley, Abhishek Chatterjee, Jeremiah W Hanes, Amrita Hazra, Steven E Ealick
Cofactor biosynthesis--still yielding fascinating new biological chemistry.
Curr Opin Chem Biol: 2008, 12(2);118-25
[PubMed:18314013] [WorldCat.org] [DOI] (P p)

Ethan Settembre, Tadhg P Begley, Steven E Ealick
Structural biology of enzymes of the thiamin biosynthesis pathway.
Curr Opin Struct Biol: 2003, 13(6);739-47
[PubMed:14675553] [WorldCat.org] [DOI] (P p)

A Marquet, B T Bui, D Florentin
Biosynthesis of biotin and lipoic acid.
Vitam Horm: 2001, 61;51-101
[PubMed:11153271] [WorldCat.org] [DOI] (P p)

T P Begley, D M Downs, S E Ealick, F W McLafferty, A P Van Loon, S Taylor, N Campobasso, H J Chiu, C Kinsland, J J Reddick, J Xi
Thiamin biosynthesis in prokaryotes.
Arch Microbiol: 1999, 171(5);293-300
[PubMed:10382260] [WorldCat.org] [DOI] (P p)


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