Difference between revisions of "BacC"

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* '''Catalyzed reaction/ biological activity:'''  
 
* '''Catalyzed reaction/ biological activity:'''  
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** oxidation of the C(7)-hydroxyl, penultimate step in bacilysine biosynthesis {{PubMed|23317005}}
  
 
* '''Protein family:''' short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)
 
* '''Protein family:''' short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bacC_3872105_3872872_-1 bacC] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bacC_3872105_3872872_-1 bacC] {{PubMed|22383849}}
  
* '''Sigma factor:''' [[SigA]] {{PubMed|19801406}}
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* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|19801406}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
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=References=
 
=References=
 
'''Additional publications:''' {{PubMed|12697329,21709425}}
 
'''Additional publications:''' {{PubMed|12697329,21709425}}
<pubmed>15609023 12372825, 21948839 19801406</pubmed>
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<pubmed>15609023 12372825, 21948839 19801406 23317005 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 18:32, 16 January 2013

  • Description: bacilysin biosynthesis oxidoreductase

Gene name bacC
Synonyms ywfD, ipa-82d
Essential no
Product bacilysin biosynthesis oxidoreductase
Function biosynthesis of the antibiotic bacilysin
Gene expression levels in SubtiExpress: bacC
MW, pI 27 kDa, 4.959
Gene length, protein length 765 bp, 255 aa
Immediate neighbours bacD, bacB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YwfD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
BacC expression.png















Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

AbrB regulon, CodY regulon, ScoC regulon

The gene

Basic information

  • Locus tag: BSU37720

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • oxidation of the C(7)-hydroxyl, penultimate step in bacilysine biosynthesis PubMed
  • Protein family: short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Jared B Parker, Christopher T Walsh
Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin.
Biochemistry: 2013, 52(5);889-901
[PubMed:23317005] [WorldCat.org] [DOI] (I p)

Takashi Inaoka, Kozo Ochi
Scandium stimulates the production of amylase and bacilysin in Bacillus subtilis.
Appl Environ Microbiol: 2011, 77(22);8181-3
[PubMed:21948839] [WorldCat.org] [DOI] (I p)

Takashi Inaoka, Guojun Wang, Kozo Ochi
ScoC regulates bacilysin production at the transcription level in Bacillus subtilis.
J Bacteriol: 2009, 191(23);7367-71
[PubMed:19801406] [WorldCat.org] [DOI] (I p)

Gerhard Steinborn, Mohammad-Reza Hajirezaei, Jürgen Hofemeister
bac genes for recombinant bacilysin and anticapsin production in Bacillus host strains.
Arch Microbiol: 2005, 183(2);71-9
[PubMed:15609023] [WorldCat.org] [DOI] (P p)

Takashi Inaoka, Kosaku Takahashi, Mayumi Ohnishi-Kameyama, Mitsuru Yoshida, Kozo Ochi
Guanine nucleotides guanosine 5'-diphosphate 3'-diphosphate and GTP co-operatively regulate the production of an antibiotic bacilysin in Bacillus subtilis.
J Biol Chem: 2003, 278(4);2169-76
[PubMed:12372825] [WorldCat.org] [DOI] (P p)