glyQ

glyQ
168

glycyl-tRNA synthetase (alpha subunit)

locus
BSU_25270
Molecular weight
33.83 kDa
pI
4.8
Protein length
Gene length
function
translation
product
glycyl-tRNA synthetase (alpha subunit)
essential
yes
ec
6.1.1.14
synonyms
glyQ, yqfJ

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0752 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,607,762 2,608,649
Phenotypes of a mutant
essential [Pubmed|12682299]
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The protein
Catalyzed reaction/ biological activity
ATP + glycine + tRNAGly --> AMP + diphosphate + glycyl-tRNAGly (according to UniProt)
Protein family
[wiki|Class-II aminoacyl-tRNA synthetase family] (according to UniProt)
Structure
[PDB|1J5W] (from ''Thermotoga maritima'', 55% identity, 72% similarity)
[PDB|6POM] (the [gene|FD84CF3E05B81BD38D8C8FF5B04728FB3912D9B5|glyQ] [wiki|riboswitch] in complex with tRNA-Gly) [pubmed|31740854]
[AF|P54380]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Expression and Regulation
Operons
genes
[gene|FD84CF3E05B81BD38D8C8FF5B04728FB3912D9B5|glyQ]-[gene|337BF226112A48C39A24E6D5C7A63F864502914C|glyS]
description
[Pubmed|22383849]
regulation
induced by glycine limitation ([protein|search|T-box]) [Pubmed|19258532,28531275]
regulatory mechanism
T-box: RNA switch, [Pubmed|19258532,28531275], in [regulon|other_regulator:T-box|T-box]
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[gene|FD84CF3E05B81BD38D8C8FF5B04728FB3912D9B5|glyQ]→[gene|337BF226112A48C39A24E6D5C7A63F864502914C|glyS]

2024-01-01 23:48:26

Jstuelk

47

e60ab43ce9617b5d52c0fddb6525c5260eb8558c

CE387EB45D5B903BD4B1766167B09E3AF4DC011E

References
Reviews
19258532
Original Publications
36815589,15378759

FD84CF3E05B81BD38D8C8FF5B04728FB3912D9B5

Page visits: 2969

Time of last update: 2024-03-27 03:05:56

Author of last update: Jstuelk