iseA

iseA
168

secreted inhibitor of cell wall endopeptidases, inhibits cell separation

locus
BSU_18380
Molecular weight
19.98 kDa
pI
10.18
Protein length
Gene length
function
protection against cell envelope stress
product
inhibitor of autolysins
essential
no
synonyms
iseA, yoeB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene
Coordinates
2,002,637  2,003,182
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The protein
Structure
[PDB|2RSX] [Pubmed|23091053]
[AF|O34841]
[wiki|Localization]
secreted [pubmed|34871030]
Expression and Regulation
Operons
genes
[gene|0CA55371306D4BD768CFA82027DCB4D581BCCB87|iseA]
description
[Pubmed|22383849]
regulation
induced by vancomycin [Pubmed|17483219]
regulatory mechanism
[protein|7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR]: repression, [Pubmed|17581128], in [regulon|protein:7F340423A34CE40D1F1AA8D373F7C4B859A6496D|walR regulon]
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[gene|0CA55371306D4BD768CFA82027DCB4D581BCCB87|iseA]

2024-01-26 02:23:52

ghost

54

2b7830044964bc8e53450ccc9fd1f01c1be1a567

ABD343C3C5C73B1AD6D40EF8CEF580B6DC21D3E0

additional information
the mRNA is cleaved by [protein|BAB297D18F94FFA67B8D12A684AB4D1BCDFB4981|RNase III] [PubMed|26883633]
Biological materials
Mutant
MGNA-B076 (yoeB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1075 NBRP B. subtilis, Japan]
BKE18380 ([gene|0CA55371306D4BD768CFA82027DCB4D581BCCB87|iseA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE18380 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTATCGCTCTCTCCTTCA,  downstream forward: _UP4_TAAGAAAAACGCCCGGTATA
BKK18380 ([gene|0CA55371306D4BD768CFA82027DCB4D581BCCB87|iseA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK18380 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTATCGCTCTCTCCTTCA,  downstream forward: _UP4_TAAGAAAAACGCCCGGTATA
References
17581128,18761694,17483219,20059685,22383849,23091053,23033921,23199363,26883633,29458655,29465029,31808740,34871030,36963396

0CA55371306D4BD768CFA82027DCB4D581BCCB87

Page visits: 3251

Time of last update: 2024-03-29 04:58:00

Author of last update: Jstuelk