yngB

yngB
168

UTP-glucose-1-phosphate uridylyltransferase, important for wall teichoic acid modification and glycolipid formation during anaerobic growth

locus
BSU_18180
Molecular weight
32.99 kDa
pI
5.2
Protein length
Gene length
function
wall teichoic acid modification and glycolipid formation under anaerobic conditions
product
UTP-glucose-1-phosphate uridylyltransferase
essential
no
synonyms
yngB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1210 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,946,702  1,947,595
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The protein
Catalyzed reaction/ biological activity
produces UDP-glucose from UTP and glucose-1-phosphate [pubmed|33556370]
Protein family
UDPGP type 2 family (with [protein|D368988F85D8436DD424B0B4A1591BDF092A8EA7|gtaB] and [protein|FC455B727F66632D94D93E103B30748944ED04A0|ytdA], according to UniProt)
Structure
[PDB|7B1R] [pubmed|33556370]
[PDB|5I1F] (from Burkholderia vietnamiensis, 50% identity)
[AF|O31822]
Paralogous protein(s)
[protein|D368988F85D8436DD424B0B4A1591BDF092A8EA7|gtaB], [protein|FC455B727F66632D94D93E103B30748944ED04A0|ytdA]
Expression and Regulation
Operons
genes
[gene|CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD|yngA]-[gene|69C5D9EF7ED43BCAB7A9D6148EDD323CE72F8E3D|yngB]-[gene|289828D37CF5422908316ED2EF1AEAE76F84161D|uptA]
description
[Pubmed|20512483]
regulation
expression during spore [wiki|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
expressed under anaerobic conditions ([protein|706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ]) [pubmed|33556370]
regulatory mechanism
[protein|706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ]: activation, [Pubmed|20512483], in [regulon|protein:706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ regulon]
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[gene|CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD|yngA]→[gene|289828D37CF5422908316ED2EF1AEAE76F84161D|uptA]

2024-03-03 16:08:58

Jstuelk

53

88307FFF5FF9989AB866CACFBDDAC58DEBA95B75

5BCC47A83DF8D622363F1295C3E4510BBE79F88C

Biological materials
Mutant
MGNA-B396 (yngB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1395 NBRP B. subtilis, Japan]
BKE18180 ([gene|69C5D9EF7ED43BCAB7A9D6148EDD323CE72F8E3D|yngB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE18180 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TCTCACTTTTTTTCTCATTC,  downstream forward: _UP4_TAAAAAAATTGTAACCATCT
BKK18180 ([gene|69C5D9EF7ED43BCAB7A9D6148EDD323CE72F8E3D|yngB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK18180 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TCTCACTTTTTTTCTCATTC,  downstream forward: _UP4_TAAAAAAATTGTAACCATCT
References
20512483,33556370

69C5D9EF7ED43BCAB7A9D6148EDD323CE72F8E3D

Page visits: 1798

Time of last update: 2024-03-28 03:52:41

Author of last update: Jstuelk