ctaE

168

cytochrome-c oxidase (caa₃) (subunit III)

locus: BSU_14910

Molecular weight: 23.12 kDa

pI: 7.41

Protein length: 207 aa

Gene length: 624 bp

function: respiration

product: cytochrome-c oxidase (subunit III)

essential: no

ec: 1.9.3.1

synonyms: ctaE

List of homologs in different organisms, belongs to COG1845 (Galperin et al., 2021)

Gene

Coordinates: 1,563,437  1,564,060

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The protein

Catalyzed reaction/ biological activity

• 4 [Fe(II)cytochrome c] + 4 H⁺ + O₂ --> 4 [Fe(III)cytochrome c] + 2 H₂O (according to UniProt)

Protein family

• cytochrome c oxidase subunit 3 family (with [protein|CD4520EF427AEFDCF028AE063BC373FA6DCE379E|qoxC], according to UniProt)

Structure

• [PDB|1FFT] (ubichinol oxidase from E. coli, 43% identity) [pubmed|11017202]
• [AF|P24012]

[wiki|Localization]

• cell membrane [Pubmed|23880299]

Expression and Regulation

Operons

• genes: [gene|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]-[gene|72D5442C0EF3B404F7B615366E357B68C863CEB6|ctaC]-[gene|20D1174554A03EECE233A1A045F6DF83AF799959|ctaD]-[gene|9DF8423F1D63ED3928B2818F58BC3DECCDBB1DDB|ctaE]-[gene|28E5AF86CE49D7B0ECBFAF9ED5C1FC65D9F810EA|ctaF]-[gene|8C16E115CB59A74C24954BFCDE112720BA09D5EA|ctaG]

  description: [Pubmed|9829923]

  regulation

  • expressed under anaerobic conditions ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]) [Pubmed|9829923]

  regulatory mechanism

  • [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|9829923], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
  • [protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh]: repression, synergistic repression with [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB], in [regulon|protein:5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, synergistic repression with [protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]

Biological materials

Mutant

• BKE14910 ([gene|9DF8423F1D63ED3928B2818F58BC3DECCDBB1DDB|ctaE]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14910 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GGTGAATTTTTCTTGAACTT,  downstream forward: _UP4_TTAATGGGGATGGTGGGATA
• BKK14910 ([gene|9DF8423F1D63ED3928B2818F58BC3DECCDBB1DDB|ctaE]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14910 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GGTGAATTTTTCTTGAACTT,  downstream forward: _UP4_TTAATGGGGATGGTGGGATA

References

Reviews

• 33705278

Original Publications

• 10551842,9829923,20817675,23880299,27503613,11017202,36422766