ctaB

ctaB
168

heme O synthase (major enzyme)

locus
BSU_14880
Molecular weight
33.79 kDa
pI
9.57
Protein length
Gene length
function
heme biosynthesis
product
heme O synthase (major enzyme)
essential
no
ec
2.5.1.-
synonyms
ctaB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0109 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,559,309  1,560,226
Phenotypes of a mutant
inactivation of ''ctaB'' facilitates without a wall (due to reduction of oxidative stress) [Pubmed|26051891]
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The protein
Catalyzed reaction/ biological activity
(2E,6E)-farnesyl diphosphate + H2O + heme b --> diphosphate + Fe(II)-heme o (according to UniProt)
Protein family
UbiA prenyltransferase family (with [protein|6CE139563BBD7C1C97AEC3AA3F88146C4EEA79E4|ctaO], according to UniProt)
Structure
[AF|P24009]
Paralogous protein(s)
[protein|6CE139563BBD7C1C97AEC3AA3F88146C4EEA79E4|ctaO]
[wiki|Localization]
cell membrane (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]-[gene|72D5442C0EF3B404F7B615366E357B68C863CEB6|ctaC]-[gene|20D1174554A03EECE233A1A045F6DF83AF799959|ctaD]-[gene|9DF8423F1D63ED3928B2818F58BC3DECCDBB1DDB|ctaE]-[gene|28E5AF86CE49D7B0ECBFAF9ED5C1FC65D9F810EA|ctaF]-[gene|8C16E115CB59A74C24954BFCDE112720BA09D5EA|ctaG]
description
[Pubmed|9829923]
regulation
expressed under anaerobic conditions ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]) [Pubmed|9829923]
regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]: activation, [Pubmed|9829923], in [regulon|protein:1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD regulon]
[protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh]: repression, synergistic repression with [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB], in [regulon|protein:5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh regulon]
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA]: repression, in [regulon|protein:E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|ccpA regulon]
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, synergistic repression with [protein|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]
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[gene|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]→[gene|8C16E115CB59A74C24954BFCDE112720BA09D5EA|ctaG]

2024-03-17 09:56:14

Jstuelk

49

57a66966d938d516e5885dbc6c6a07dd7fdfd454

61117927D388B0F9733EEB1889206DE9FFA99028

Biological materials
Mutant
BKE14880 ([gene|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14880 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAACGTAAACCTCCCTTA,  downstream forward: _UP4_TAAAAAATAGATATGATGCT
BKK14880 ([gene|83F5D5FCCAFADB7231ACD9BE7941820240954C70|ctaB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14880 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATAACGTAAACCTCCCTTA,  downstream forward: _UP4_TAAAAAATAGATATGATGCT
Reviews
35630371
References
7968515,15491161,9829923,19204012,26051891

83F5D5FCCAFADB7231ACD9BE7941820240954C70

Page visits: 4351

Time of last update: 2024-03-29 06:06:26

Author of last update: Jstuelk