lnrK

lnrK
168

two-component response regulator, involved in resistance to linearmycin

locus
BSU_08300
Molecular weight
24.22 kDa
pI
4.67
Protein length
Gene length
function
resistance to linearmycin
product
two-component response regulator
essential
no
synonyms
lnrK, yfiK

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2197 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
905,010  905,672
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The protein
[wiki|Domains]
[wiki|Response regulatory domain] (aa 3-119) (according to UniProt)
[wiki|HTH luxR-type domain] (aa 151-216) (according to UniProt)
Structure
[PDB|5HEV] ([protein|search|LiaR ]from Enterococcus faecium, 42% identity) [pubmed|27670715]
[AF|P94439]
Modification
phosphorylated by [protein|03AEADB134F1CAD8BBB3E1F625D597EBA1FDA30B|lnrJ] on an Asp residue
Paralogous protein(s)
[protein|49E70A20CC05DBE485953C0AE34E634EFB33C3B2|liaR], [protein|DD799ED3EB79457C27ED30C7B4DBBC2C8F962191|yhcZ], [protein|EFEAF09E4449A022A7323450FDED9458426A0080|ydfI], [protein|23F365C23BDEE02D42C9355FC7D2A65DAF9F79ED|yxjL]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|03AEADB134F1CAD8BBB3E1F625D597EBA1FDA30B|lnrJ]-[gene|387EF370CE24F7A3C20789A57329A02EBED46F53|lnrK]
description
[Pubmed|8973323]
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[gene|03AEADB134F1CAD8BBB3E1F625D597EBA1FDA30B|lnrJ]→[gene|387EF370CE24F7A3C20789A57329A02EBED46F53|lnrK]

2024-03-23 15:09:22

ghost

44

3b2b211fdc6c1d8b24be84dbf8fea053f5e2ae75

2539EB691EC0C9828A8B7F8DE3013CDBCEF4A1D3

Biological materials
Mutant
MGNA-C301 (yfiK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2299 NBRP B. subtilis, Japan]
BKE08300 ([gene|387EF370CE24F7A3C20789A57329A02EBED46F53|lnrK]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE08300 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATCGTCGGTAATGATGATCT,  downstream forward: _UP4_TGACATATGACGTTTTGCAT
BKK08300 ([gene|387EF370CE24F7A3C20789A57329A02EBED46F53|lnrK]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK08300 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATCGTCGGTAATGATGATCT,  downstream forward: _UP4_TGACATATGACGTTTTGCAT
References
10094672,8973323,26647299,28461449,27670715,32973732

387EF370CE24F7A3C20789A57329A02EBED46F53

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Time of last update: 2024-03-28 18:00:34

Author of last update: Jstuelk