phrH

168

secreted regulator of the activity of phosphatase [protein|BA85E2C2E2A6B76FAFA31EBDBF466324C9B021C8|rapH]

locus: BSU_06839

Molecular weight: 6.30 kDa

pI: 9.518

Protein length: 57 aa

Gene length: 174 bp

function: control of [wiki|sporulation] initiation

product: secreted regulator of the activity of phosphatase [protein|BA85E2C2E2A6B76FAFA31EBDBF466324C9B021C8|rapH]

essential: no

synonyms: phrH

List of homologs in different organisms

Gene

Coordinates: 752,079  752,252

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The protein

Protein family

• [wiki|phr family] (according to UniProt)

Structure

• [AF|Q59HN7]

[wiki|Localization]

• secreted as hexapeptide TDRNTT [Pubmed|21908671], uptake by the ([protein|05752B9C4EA7ACD579D65D028B7DF1861F3840CB|oppD]-[protein|38AD697B6C9967B8BD7496E31264A21F6D0A9DEE|oppF])-([protein|B0A3C7B253FB1DA1D4BC9D1D564905ECE8A65BC1|oppB]-[protein|DDBCE73B6AF39E5D669475479186C93F287DA9FC|oppC])-[protein|302DFA46D73E18C4663468ED6033C55056744475|oppA] [wiki|ABC transporter] [Pubmed|21908671]

Expression and Regulation

Operons

• genes: [gene|4FA7D6E6316A6FC71C10C692D125833263894020|phrH]

  description: [Pubmed|21908671]

  regulation

  • ''[protein|search|rapH]'': repressed by [protein|search|RghR] [Pubmed|16553878]

  regulatory mechanism

  • [protein|972401B6AF56EC67FE6F1C3FEA9E2A9FC77C7672|rghR]: repression, [Pubmed|16553878], in [regulon|protein:972401B6AF56EC67FE6F1C3FEA9E2A9FC77C7672|rghR regulon]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21908671], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]

• genes: [gene|BA85E2C2E2A6B76FAFA31EBDBF466324C9B021C8|rapH]-[gene|4FA7D6E6316A6FC71C10C692D125833263894020|phrH]

  description: [Pubmed|21908671]

  regulation

  • ''[protein|search|rapH]'': repressed by [protein|search|RghR] [Pubmed|16553878]

  regulatory mechanism

  • [protein|972401B6AF56EC67FE6F1C3FEA9E2A9FC77C7672|rghR]: repression, [Pubmed|16553878], in [regulon|protein:972401B6AF56EC67FE6F1C3FEA9E2A9FC77C7672|rghR regulon]
  • [protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]: activation, [Pubmed|11948146,11918817], in [regulon|protein:08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK regulon]
  • [protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]: repression, [Pubmed|20817675], in [regulon|protein:E5110D9C36E8C55AFD1419987B14A53232165F20|abrB regulon]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|21908671], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]

Biological materials

Mutant

• BKE06839 ([gene|4FA7D6E6316A6FC71C10C692D125833263894020|phrH]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE06839 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AGCCAGACACATCATCACTT,  downstream forward: _UP4_TAGGGCTTTTTCTTGCTTTA
• BKK06839 ([gene|4FA7D6E6316A6FC71C10C692D125833263894020|phrH]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK06839 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AGCCAGACACATCATCACTT,  downstream forward: _UP4_TAGGGCTTTTTCTTGCTTTA

References

Reviews

• 37042030

Original Publications

• 16553878