gamR

gamR
168

transcriptional repressor ([wiki|GntR family]) of the [gene|8BBC9AFF4CD56A3A66E270A2BBA193D095EE01D1|gamA]-[gene|4DF1740D4DFB9FD25E77C14D28AEA01707776099|gamP] operon

locus
BSU_02370
Molecular weight
26.45 kDa
pI
5.56
Protein length
Gene length
function
regulation of glucosamine utilization
product
transcriptional regulator ([wiki|GntR family])
essential
no
synonyms
gamR, ybgA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2188 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
257,791 → 258,498
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The protein
Protein family
[wiki|GntR family] of transcription factors
[wiki|Domains]
[wiki|HTH gntR-type domain] (aa 2-70) (according to UniProt)
Structure
[PDB|2WV0] ([protein|6D36D6360FE1CBFF5F64B2A6D1406405D6C6F7D5|nagR], 34% identity) [pubmed|20047956]
[AF|O31459]
Effectors of protein activity
glucosamine-6-phosphate acts as molecular inducer that prevents GamR from binding to its operator sites in the promoter regions of the [gene|8BBC9AFF4CD56A3A66E270A2BBA193D095EE01D1|gamA]-[gene|4DF1740D4DFB9FD25E77C14D28AEA01707776099|gamP] and [gene|FB074E8CFCA1C0198457170A7AFD85C875B34DF2|gamR]-[gene|2E0FBCA66FB88EDFD345FA289F776C7CA23976F5|ybgB]  operons [Pubmed|24673833]
Expression and Regulation
Operons
genes
[gene|FB074E8CFCA1C0198457170A7AFD85C875B34DF2|gamR]-[gene|2E0FBCA66FB88EDFD345FA289F776C7CA23976F5|ybgB]
description
[Pubmed|23667565]
regulation
induced by glucosamine ([protein|search|gamR]) [Pubmed|24673833,23667565]
induced by glucosamine ([protein|search|GamR]) [Pubmed|24673833,23667565]
regulatory mechanism
[protein|FB074E8CFCA1C0198457170A7AFD85C875B34DF2|gamR]: repression, [Pubmed|24673833,23667565], in [regulon|protein:FB074E8CFCA1C0198457170A7AFD85C875B34DF2|gamR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|23667565], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|FB074E8CFCA1C0198457170A7AFD85C875B34DF2|gamR]→[gene|2E0FBCA66FB88EDFD345FA289F776C7CA23976F5|ybgB]

2024-02-15 07:13:14

ghost

52

23ad24e5d0f0ebe864f8ce62d459ff58ea2562d9

E34905CD5A79F10FB8D4BF3FBA89AF47E5096F33

Biological materials
Mutant
BKE02370 (Δ[gene|FB074E8CFCA1C0198457170A7AFD85C875B34DF2|gamR]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE02370 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTCATTCTCCCCATTCT,  downstream forward: _UP4_TAAAGCAATGTGTTTTAAGA
BKK02370 (Δ[gene|FB074E8CFCA1C0198457170A7AFD85C875B34DF2|gamR]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK02370 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTTCATTCTCCCCATTCT,  downstream forward: _UP4_TAAAGCAATGTGTTTTAAGA
References
Reviews
26159076
Original Publications
10627040,23667565,24673833,20047956

FB074E8CFCA1C0198457170A7AFD85C875B34DF2

Page visits: 2698

Time of last update: 2024-03-19 05:14:36

Author of last update: Melvin.boenninger