AseR

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  • Description: transcriptional repressor of aseA and aseR

Gene name aseR
Synonyms ydeT
Essential no
Product transcriptional repressor (ArsR family)
Function regulation of As (III) efflux
Gene expression levels in SubtiExpress: aseR
MW, pI 12 kDa, 6.307
Gene length, protein length 333 bp, 111 aa
Immediate neighbours ydzO, aseA
Sequences Protein DNA Advanced_DNA
Genetic context
YdeT context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
AseR expression.png
























Categories containing this gene/protein

transcription factors and their control, resistance against toxic metals

This gene is a member of the following regulons

AseR regulon

The AseR regulon:

The gene

Basic information

  • Locus tag: BSU05330

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: As(III) acts as molecular inducer PubMed

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulatory mechanism:
    • AseR: transcription repression (autorepression) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Duncan R Harvie, Claudia Andreini, Gabriele Cavallaro, Wenmao Meng, Bernard A Connolly, Ken-ichi Yoshida, Yasutaro Fujita, Colin R Harwood, David S Radford, Stephen Tottey, Jennifer S Cavet, Nigel J Robinson
Predicting metals sensed by ArsR-SmtB repressors: allosteric interference by a non-effector metal.
Mol Microbiol: 2006, 59(4);1341-56
[PubMed:16430705] [WorldCat.org] [DOI] (P p)

Charles M Moore, Ahmed Gaballa, Monica Hui, Rick W Ye, John D Helmann
Genetic and physiological responses of Bacillus subtilis to metal ion stress.
Mol Microbiol: 2005, 57(1);27-40
[PubMed:15948947] [WorldCat.org] [DOI] (P p)