asd

168

aspartate-semialdehyde dehydrogenase

locus: BSU_16750

Molecular weight: 37.69 kDa

pI: 4.97

Protein length: 346 aa

Gene length: 1041 bp

function: biosynthesis of threonine, lysine, dipicolic acid, peptidoglycan

product: aspartate-semialdehyde dehydrogenase

essential: yes

ec: 1.2.1.11

synonyms: asd

List of homologs in different organisms, belongs to COG0136 (Galperin et al., 2021)

Gene

Coordinates: 1,745,991  1,747,031

Phenotypes of a mutant

• essential [Pubmed|12682299]

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The protein

Catalyzed reaction/ biological activity

• L-aspartate 4-semialdehyde + NADP⁺ + phosphate --> 4-phospho-L-aspartate + H⁺ + NADPH (according to UniProt)

Protein family

• aspartate-semialdehyde dehydrogenase family (single member, according to UniProt)

Structure

• [PDB|2GYY] (from ''Streptococcus pneumoniae'', 52% identity, 65% similarity) [Pubmed|16895909]
• [AF|Q04797]

Modification

• phosphorylation on Ser-98 AND Tyr-146 [Pubmed|17218307]

References

• 8345520,15699190,8098035,17218307